Can you drive it? Yes.
Should you drive it? Depends on how well you break in the engine. Your engine needs to be able to get up to normal operating temps for sustained periods of time. It also needs to cool off at a normal rate. Colder temps tend to stop both from happening.
If you must run in the cold or break in an engine in the cold, I suggest you get a hand held hair dryer and an extension chord. Use the hair dryer to pre-heat the engine prior to attempting to start it.
To help the engine attain and maintain its normal operating temp, you might need to wrap the cooling head as others have mentioned (not something I recommend, but others swear by it) and make certain you run with the body on (hopefully you have not ventilated it yet). The lower air flow over the cooling head will help it heat up quickly and stay hot.
After the fuel tank empties from running, get that hair dryer on the engine again (high setting at first...then to the low setting...then to off). Do this over about a five minute period to allow the engine to gradually cool down. Rapid cooling of parts (especially dissimilar metals) will cause metals to warp and other bad things.
To be totally safe, you might want to wait until Spring.