The bigger tires go over obstacles better than small tires. Small tires are lighter and spin faster. You can’t get a big giant tire to move under a body or turn as sharp as a small tire. That is of corse giver the same suspension. It’s a real test and tune thing.
With portals some times the smaller rims are a problem. So 2.2 rims 1.9 tires are a popular choice. Personally I have gotten my best performance from 1.9 with good foams. But the terrain makes the difference.