I just had a dried out/shrunken HSN o-ring give me fits the other day. Guess that's what happens when you fire up a nitro once every other year. lol! Stupid thing was screwing itself in/out as it ran. Would be pig rich one minute, then screaming mimi lean the next.
Any time I get a used engine, if it has compression, I take it completely apart, clean it, inspect it, looking for wear in the con-rod, bearings and cracks in the crank case, seal the typical spots with RTV (not really necessary if the o-rings are good), set the carb to factory, replace o-rings/gaskets if I have them and start from there. Then at least I know all the screws are tight and there aren't any apparent mechanical issues inside.
Regardless though, any time I get a used truck with a used engine on it, I consider the engine garbage and treat it as such until proven otherwise. I typically replace them with a new engine anyway, or at least one I broke-in and have on hand.