Question though. Do you backup system files, games, and other software as well?
I do not. My setup consists of using a
Synology DS412+ as my central location for all my files. I create a network share folder called profile on the Synology and change the default Windows location of my "My Documents", "Videos" and "Pictures" folders. I don't play much games but the one or two I still do play keep their saved files in my My Documents (which as mentioned above is going to my Synology).
In addition I also install a program called CloudStation, which is similar to DropBox but is ran from my Synology so I control the data and don't have to give up my files to some company. It's all stored on my Synology. This allows me to keep files I want across all my devices like on my phone, laptop and tablet all synced together. Another nice feature I really love about my Synology is that I can then install an app called PhotoStation on my Synology and cell phones, which then automagically uploads all of my pictures I take on my phone and uploads them to my Synology... my phone gets lost, stolen or broken? No problem, all my photos are saved on my Synology.
On the Synology, from there I install CrashPlan which I have setup to backup everyone on my Synology to CrashPlan. This allows me to keep all my files in an easy to manage central location, offering a RAID-10 protection, which is backed up using the single computer unlimited account. Otherwise I would need to use CrashPlan on all my computers and laptops which costs more.
All that said, if someone is looking for a easy to use, simple to setup, and a set it and forget it configuration then I'd recommend installing CrashPlan directly on your computer and have it backup your entire hard drive. Since you get unlimited storage, why not? It's also much easier for most users to do this as they may or may not know where everything is actually stored on the computer so if they protect the entire thing, most of it will be un-needed but you're certain to get everything backed up.