From what i've read and found, it's not always true that bigger is more powerful. It all depends on the maker's design. Better porting, better carb, better exhaust... these are what makes for high horsepower.
Typically with bigger, you get more low end torque.
I run an XTM conversion with an OS 21 RG-X (P). I've replaced every gear i can in the trans and spur with RRP steel. As for the diffs, shimming correctly to the appropriate slop will extend the life. RRP's diff gears don't seem to be any bettor or worse than stock. Aside from the fact that you can buy 2-3 sets of stock for one set of RRP.
You may want to go with maximizer's diff cups though. These help with the life of the diffs as well.
I've replaced as much as i can with aluminum, titanium and steel. Trans, diff cases and bulks are all aluminum. Bulkhead braces are titanium. All of this helps to prevent chassis flex from the 21's power/torque. Adding the al trans case really helped with this.
XTM includes drive shafts with their kits. Although, XTM's are relatively weak from personal experience and what i've read. But, they are only $25 a pair.
Hope this is of some use.