Well, it depends.
.12, .15, .18, .21, .28, .30 = cubic inch (ci)
2.5 = cubic centimeter (cc)
The most used:
Generally considered small block:
1.97cc (possibly 2.0) = .12ci (many 1/10 race engines and older 1/10 RTR engines)
2.5cc = .15ci (traxxas 2.5, 2.5R, OS 15 CV and many others)
3.0cc = .18ci (HPI 3.0, OS 18TM/TZ)
Considered "mid-block" (big block power/capacity in a small block crank case):
3.3cc = .20ci (traxxas 3.3, probably other .20's, just don't know them)
3.4cc = .21ci (OS21TM and others)
4.27cc=.26ci (Picco 26 Maxx and others for the t-maxx/revo)
Generally a true big block crank case:
3.4cc = .21ci (many big block 21 race and RTR engines)
4.1cc = .25ci (HPI 25)
4.27cc=.26ci (losi/dynamite 427, M26, M26SS)
4.6cc = .28ci (many big block 28's)
4.9cc = .30ci
You will notice that there are a few engines with "big block" capacity, but are built for a "small block" vehicle. Kind of a way to get a lot of power more cheaply than getting a really high end Italian mill to throw in a t-maxx. Not exactly always "cheap", but generally more so than a race engine.