Yes. Until your at about 1/3 open throttle, the LSN is doing most of the fuel control.
The HSN (high speed needle) has two functions:
1) Over all fuel flow
2) High speed tune (from 1/3-WOT)
The LSN only affects the engine from idle to about 1/3 open throttle.
Considering the HSN controls fuel flow overall, it will affect the LSN adjustment.
Say for instance, you screw the HSN all the way in. Regardless how you set the LSN, fuel will not flow into the engine, because the HSN is shutting off the entire fuel flow.
But, say you have the HSN set too rich for high speed use, you could still have your LSN set properly for idle and it will get blubbery rich as you open the throttle as the HSN takes over.
I'd just make sure the LSN is set flush with the LSN housing, the HSN set 3-4 turns out from bottom, then start from there. It should be rich, but run.
On a side note, here's a tuning guide that I've found in the past and I really like how things are explained. It's helped me become a more proficient tuner:
http://www.nitroreview.com/hintstips/ParisRacingEngineTuningTechTips.pdf
It's a lot of reading, but it contains a lot of good info for people who already "know" how to tune and people who are new to the hobby or never got good at tuning.
As for the fuel your using, I couldn't say. A lot of traxxas owners swear by it. I've never used it, but I've run traxxas engines. I now use byrons 25% nitro/11% oil fuel. Burns good, starts easy, solid power and runs pretty cool. I ran trinity MHP 20% for years until this past year. The manual for my new LRP28 in my aftershock suggested 25% nitro was as low as I should go. So, now I run it in my XTM24.7 powered buggy, my 18TM jato (or trx2.5 when it's installed) and my LRP28 aftershock. Runs good in all three engines. Although, I have an OS21RG in my aftershock now that it's winter (didn't want to shorten the life of the LRP I bought this spring), and it seems to run easily on the fuel as well. But, it's an OS, they can run on mud if you know how to tune
