I don't know much about vantage parts. Metal ones will wear over time, but if they are decently made, they should hold up for a while.
The reason I asked if this was your first is because a lot of new people don't understand the problem high rpm's and rotational mass can cause to a drivetrain. Take your S10, put it up on jacks, spool the tires up to about 100mph then drop it off the jack... stuff will break.
This is essentially what a lot of newer guys are doing when they land their RC's off jumps while still pinning the throttle. No amount of aftermarket parts is going to put up with that kind of abuse. I'm not saying it's what your doing, but more something to look out for even with your new axles. They will snap like twigs if you don't drive it with that in mind.
It's odd that your having this much of a problem with it chewing up axles. The OS21TM is a solid engine, but I'd expect you to fry trans gears before outer wheel axles. Especially since your running revo spec axles. The spool doesn't help though.
I think gearing it up a bit and adjusting your shift point should help relieve some of the strain. Again, unlike in your S10 (assuming it's not an automatic), there isn't a clutch to engage 2nd. It slams into gear like launch control on a porche. The higher the RPM's are before it shifts, the harder it's going to "hit" when 2nd kicks in. Since you seem to have the power to pull 2nd gear without much issue, use first gear just to get it moving or to putt around slowly, but then 2nd gear will be engaged lower in the torque curve of the engine and you can use the brute power of the engine to compensate.
Gearing it up a bit will also relieve some of the strain.