I find it hard to believe that Losi would let the engines go out the door with randomly set LSNs and HSNs.
Here is what they recommend in the manual: Typically, the high speed needle will need to be adjusted 2 - 3 full turns open, and the low speed needle about 2 full turns open.
And yes you will have to adjust the settings. Fuel to air mixture is affected by air temp, humidity, barometric pressure, so unless you live in a sealed bubble you'll need to make some kind of adjustments.