Sorry, must have missed this thread earlier.
First off, I have no experience with anything larger than a .21. I have seen some .26's / .27's run but that's it. I've had bad experiences with Sirio's, they seem to be hit or miss. If you get a good one they are one of the best engines you will find. If you get a bad one expect 3 minute run times and then a flame out for no apparent reason. I wouldn't be afraid of trying a turbo plug though.
The 421b is a new engine and little is known about it as of yet. I was very close to getting one but backed off at the last minute and got a P5. Early report is they were designed for euro style tracks and are more of a top-end engine, but that's mainly hearsay. I haven't ran one nor seen one run.
I've had a few P5's and I really like the engine, probably my favorite of them all. My suggestion, get a P5 and send it to Ed at EBMods, you won't regret it. That's what I'm running now and it's pretty tough. I only have a gallon through it so far and it is the fastest engine I have ran. Little pickier to tune compared to the standard P5 but not impossible to tune. Nova engines overall are pretty reliable and you should expect to get around 5 gallons through it before a rebuild.
The RB's are nice and powerfull, but you will have to play with tuning the clutch and pipe to get the most out of them. Especially with the C5 if you are trying to get some bottom end out of it. It is ballistic from mid to top though. The WS7II is a good engine from top to bottom. A little work with the clutch helps this engine alot also. RB's will run forever on a piston and sleeve, change the rod about every 2-3 gallons.
All of the engines you named are pricey, so let me throw a couple of other engines out here for you to consider.
Medial Pro M2K (Nova based).....It is another high end engine which is modified by JP. A little stronger than the WS7II on bottom and top. Pretty easy to tune, should be able to get 5-6 gals through it before rebuild. Plus, the craftsmanship and mod job on this engine are amazing.
JP FX series......A new engine coming out this month. I would expect it to be another high end engine. Anything with JP's initials attached are top notch in quality.
Of the engines mentioned, especially the WS7, M2K, and P5, go with an 86 or OS 2050 pipe. They are the best 2 pipes for these engines.