Apart from turning the idle screw in a little just to keep it running, (which you may have to turn back out a little once tuned) You should remember this.
LSN (low speed needle) Turn in at 1/8 at a time to improve throttle response, once the response does not change then back it off a little.
HSN (high speed needle) turn in at 1/8 at a time to improve your overall running and top speed.
Always start with a full tank but dont start tuning until about half a tank when the mill is good and hot otherwise you tend to suffer from a savage dissorder called half tank leaning. When you have it sort of tuned and you notice that the engine revs seem to be a little high when you slow to a stop then turn the LSN out by an 1/8 of a turn.
If your not racing in a club and your just doing some general bashing like most of us then run the beast rich (too far out on HSN, too much fuel, lots of smoke) then your mill will still perform well but it will be getting more lube from the fuel to help keep cool. Invest in a temp monitor, they dont cost much and can help you make your mill last and run for longer.
Wow, can i waffle on or what. Sorry for getting carried away but i have been there and done that and was grateful for the help i recieved, mostly off this site. Good luck