If you tune the engine when the tank is half full, the end result will be that the engine runs a little rich with a full tank, just right when the tanks is half full and it will be a little lean as the tank empties. This means that performance will actually increase as the tank empties, and you will run a little cooler for the duration of the tank as it will be at a rich setting from full tank to about the halfway mark. Rich setting means cooler running.